0924国际期刊速递丨今日热点心脏

白癜风的危害是什么 http://pf.39.net/bdfyy/zqbdf/150314/4591208.html
TODAY今日发布JAMACardiologyEarlyRecent,Sept23,今日发布07篇CirculationEarlyRecent,Sept23,今日发布01篇JAMAEarlyRecent,Sept23,今日发布03篇NEJMSept24,:(13)今日发布23篇JThromb?ThrombolysisEarlyRecent,Sept24,今日发布01篇StrokeEarlyRecent,Sept24,今日发布01篇CirculationEarlyRecent,Sept24,今日发布01篇ATVBEarlyRecent,Sept24,今日发布02篇HypertensionEarlyRecent,Sept24,今日发布01篇RECOMMEND推荐阅读01VWF（von-WillebrandFactor）是饮食诱导肥胖小鼠深静脉血栓形成的关键介质ATVBresearch-articleAlisonMichels,CourtneyN.Dwyer,etc.2小时前等36用户推荐阅读本文Objective:Obesityischaracterizedbychroniclow-gradeinflammationandconsequentiallyahypercoagulablestate,associatingwithanincreasedincidenceofvenousthromboembolism.IncreasedVWF(vonWillebrandfactor)plasmaconcentrationandprocoagulantfunctionareindependentriskfactorsforvenousthromboembolismandareelevatedinobesepatients.Here,weexplorethepathobiologicalroleofVWFinobesity-associatedvenousthrombosisusingmurinemodels.肥胖症的特点是慢性轻度炎症和随后的高凝状态，与静脉血栓栓塞症的发病率增加有关。血浆VWF（vonWillebrandfactor）浓度和促凝血功能增加是静脉血栓栓塞的独立危险因素，肥胖患者的VWF升高。在此，我们利用小鼠模型探讨VWF在肥胖相关静脉血栓形成中的病理生物学作用。ApproachandResults:Wefirstshowedthatdiet-inducedobesemicehaveincreasedVWFplasmalevelsandFVIII(factorVIII)activity

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